"Somewhere in the system, misinformation is generating the over production of skin cells. Where would cannabinoids enter into this situation and restore homeostasis? How best would it be delivered internally? Thank you"
Psoriasis is a complex rheumatologic disorder that most classically manifests with painful and irritating skin plaques. However, there are several different psoriasis subtypes that can require different types of treatment, particularly psoriatic arthritis. As you pointed out, the skin manifestation of psoriasis has been associated with rapid and dysregulated skin cell production. There have been studies showing that cannabinoid receptors are found in the skin and that cannabinoids can slow cell turn over by binding these receptors.
The best approach to treatment for psoriasis is to work with your rheumatologist and/or dermatologist. There is usually a step-wise approach ranging from topical steroids, to phototherapy, to immunosuppressive therapy based on the subtype and severity of your psoriasis. Similarly, a cannabis-recommending physician may suggest a localized topical product like a cannabinoid infused ointment. Generally, a fat-based topical ointment is more preferable than a water-based lotion. A systemic cannabis product such as an oral cannabinoid infused tincture may be useful based on your specific psoriasis symptoms.
Psoriasis is also associated with tobacco smoking and obesity. Maintaining a healthy diet, regular exercise routine, and avoiding tobacco products are critical for the management of psoriasis. Given the relationship between tobacco smoking and psoriasis, it may not be advisable to consume smoked cannabis for the treatment of psoriasis of any subtype.
Wilkinson JD, Williamson EM. Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J Dermatol Sci. 2007 Feb;45(2):87-92
I like Dr Sank’s answer and want to add that psoriasis often is due to Vitamin D and zinc deficiency and the CBD cannabis, low THC in a medium chain triglyceride oil helps to stop the internal inflammation that may affect the joints. The topical CBD cannabis will stop the local irritation for about 4-6 hours but it may be repeated frequently and will not make you high.
Try to get & keep your blood level of 25-OH D (Vitamin D3) above 50 ng/ml for optimum health and resolution of the inflammation.
I usually recommend you try sprouting organic quinoa and using it raw in your foods to add a non-inflammatory type of protein that also stimulates the immune system in your G.I. tract.
Check it out, you may actually heal your psoriasis.
If you are not healed you must ask yourself, "What has me so irritated?" Let that go, really let that go and you likely will notice the improvement. When we carry problems around on our skin, others don’t have to carry the problems because we’re already doing it…..
Think about it.