Try with food and try without and see what works best for you. Tinctures work best if they are absorbed in the mouth by the mucous membranes. To make the most out of a tincture one should remove excess saliva in the mouth before applying under the tongue. Allow the liquid to remain under the tongue for as long as possible. This will allow the active compunds to be move quickly into the bloodstream. Tinctures can also be utilized by adding to food or drinks, however it will take longer for the effects to be felt, and a larger percentage of the medicine will pass through the digestive system and into the toilet bowl. The condition that you are treating will also determine the best method of using a tincture, so experiment with different formulations and methods.