OG Kush is a very well known indica strain that is thought to have come from bag seed in the early 90s. It was brought from Florida to Colorado and California.
It is interesting in that it is purported to reduce anxiety while still producing euphoric / uplifting effects. Therefore, for an indica, it is unlikely to cause depression or worsen depression; and it may actually improve depression.
It may be helpful for patients that suffer both anxiety and depression, as well as patients with ADHD, chronic pain, and migraine headaches.