Top 5 Marijuana Strains to Fight Fatigue

While many people still assume cannabis can only be used to relax and slow down, certain marijuana strains can significantly boost energy and productivity. Most of us experience lethargy at one point or another, whether it stems from lack of sleep, illness or depression. That lethargy can make it hard to get out of bed and be productive throughout the day. And it can make it difficult to concentrate or stay awake.

While caffeine is probably the most popular stimulant used around the world to combat fatigue, cannabis can be just as—if not more—effective. And it won’t cause the afternoon crash that you may experience after drinking a cup of coffee in the morning.


When ingesting marijuana to fight fatigue, there are a few methods that can be effective. Smoking or vaping are the best choices if you want to feel immediate effects, while edibles or capsules will provide a longer-lasting boost of energy.

Generally, sativa or sativa-dominant hybrid strains are known for their energizing, active effects. Beyond that, the potency, flavor and balance in terms of the effect on the body and mind will differ depending on the synergistic qualities of tetrahydrocannabinol (THC), cannabidiol (CBD), terpenes and other cannabinoids present in a given cannabis strain. Check out our round-up of the top five marijuana strains that can help fight fatigue and increase motivation.

1. Jack Herer

Fatigue-fighting marijuana strain: Jack Herer

A world-renowned strain named after the cannabis activist and author, Jack Herer is an upbeat sativa strain that increases energy and creativity. While the high THC content (23%) puts this strain on the more potent side, patients describe the experience as clear-headed, focused, and blissful, making it ideal for daytime motivation and productivity. Also a mood elevator, Jack Herer is effective for patients with mental or neurological disorders, anxiety, PTSD, ADHD, and migraines, Jack Herer is a three-way cross of Haze hybrid, Northern Lights #5 , and Shiva Skunk.

2. Juicy Fruit

Fatigue-fighting marijuana strain: Juicy Fruit

Juicy Fruit is a flavorful hybrid tastes like a cup of fruit punch or a pina colada. A cross of Afghani indica and pure Thai sativa with up to 20% THC, the sativa-dominant Juicy Fruit has powerful effects on both the head and body. The experience is mentally euphoric and physically relaxing yet energizing, making it ideal for patients dealing with anxiety, mood disorders, depression, and physical pain.

3. Durban Poison

Fatigue-fighting marijuana strain: Durban Poison

Durban Poison is a pure sativa and is one of the most energetic and powerful strains in the world, with up to 24% THC content. The effects are strong, bringing feelings of happiness and extremely high energy. Ideal for daytime productivity, this strain is effective for patients dealing with depression, anxiety, and chronic pain. Anxiety-prone users should be careful not to consume too much to avoid possible paranoia. Durban Poison is also known to help reduce food cravings and promote weight loss.

4. Harlequin

Fatigue-fighting marijuana strain: Harlequin

Harlequin is well-known for its high CBD content, Harlequin offers a more mellow, balanced experience. The consistent 5:2 CBD to THC ratio makes this one of the most popular CBD strains, particularly useful for treating pain and anxiety. The effects are calming and relaxing, while maintaining focus and alertness, so patients can remain awake and productive without an overwhelming buzz.

5. Green Crack

Fatigue-fighting marijuana strain: Green Crack

The name, Green Crack can be intimidating to some, but this sativa strain is useful for the boost of energy and focus it creates. With up to 24% THC content and a sweet, tropical flavor, Green Crack is a popular strain that can be found almost anywhere. A descendant of Skunk #1, this strain enhances creativity and productivity, and can be used to treat fatigue, stress, ADHD, migraines, and depression.

If you’re new to cannabis and want to learn more, take a look at our Cannabis 101 post. HelloMD can help you get your medical marijuana recommendation; it’s 100% online, private and efficient


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