Hello! Do you mean derealizatoin- depersonalization disorder? From what I understand, this disoder is most often seen from victims of trauma. I suspect that it may be related to multiple personality disorder or what is now known as dissociative identity disorder; however, as a caveat I’m not a trained as a psychiatrist and this is only a hypothesis. I think med cann can be used but I would only do so with small amounts/ %’s. My guess is that lower THC strains would probably be best. However, the gold-standard for treatment is behavioural treatment therapy / talk therapy. I would NOT use cannabis to try to treat this on your own , the same recc’ I make to all patients w/ mental health issues interested in using med cannabis. I hope this helps!